Abstract | OBJECTIVES: To investigate the effects and mechanism of Frondanol-A5P, a polar extract from Cucumaria frondosa, on growth inhibition and apoptosis in S2013 and AsPC-1 human pancreatic cancer cells. METHODS: RESULTS: CONCLUSIONS: Frondanol-A5 causes cell cycle arrest and apoptosis in human pancreatic cancer cells. These changes are associated with decreased expression of cyclin A, cyclin B, and cdc25c and increased expression of p21 that, at least in part, is mediated by a p38 kinase-dependent mechanism. Because Frondanol-A5P is derived from an edible, nontoxic, sea cucumber, it may be valuable for nutritional therapy or prevention of pancreatic cancer.
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Authors | Alexandra B Roginsky, Xian-Zhong Ding, Carl Woodward, Michael B Ujiki, Brahmchetna Singh, Richard H Bell Jr, Peter Collin, Thomas E Adrian |
Journal | Pancreas
(Pancreas)
Vol. 39
Issue 5
Pg. 646-52
(Jul 2010)
ISSN: 1536-4828 [Electronic] United States |
PMID | 20124937
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Annexins
- Antineoplastic Agents
- Cell Cycle Proteins
- Complex Mixtures
- Frondanol-A5P
- p38 Mitogen-Activated Protein Kinases
- Caspase 3
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Topics |
- Animals
- Annexins
(metabolism)
- Antineoplastic Agents
(pharmacology)
- Apoptosis
(drug effects)
- Caspase 3
(metabolism)
- Cell Cycle
(drug effects)
- Cell Cycle Proteins
(metabolism)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Complex Mixtures
(pharmacology)
- Cucumaria
- Humans
- Pancreatic Neoplasms
(metabolism)
- Phosphorylation
- p38 Mitogen-Activated Protein Kinases
(antagonists & inhibitors)
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