Abstract |
Over-expression of multidrug resistance (MDR) proteins PGP and BCRP has a negative prognostic impact in acute myeloid leukemia (AML) patients. Inclusion of fludarabine in induction chemotherapy increases remission rate in PGP over-expressing cases. We investigated the role of BCRP in 138 adult AML patients receiving induction therapy with fludarabine. None of the MDR-related proteins influenced complete remission attainment. Conversely, high levels of BCRP significantly affected disease-free survival, as higher relapse rates (48.5% vs 28.5%) and earlier relapse occurred in BCRP+ patients. Also overall survival was affected by BCRP positivity, and survival significantly worsened in case of concomitant PGP and BCRP over-expression.
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Authors | Daniela Damiani, Mario Tiribelli, Angela Michelutti, Antonella Geromin, Margherita Cavallin, Dora Fabbro, Annalisa Pianta, Michele Malagola, Giuseppe Damante, Domenico Russo, Renato Fanin |
Journal | Leukemia research
(Leuk Res)
Vol. 34
Issue 7
Pg. 942-5
(Jul 2010)
ISSN: 1873-5835 [Electronic] England |
PMID | 20122734
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2010 Elsevier Ltd. All rights reserved. |
Chemical References |
- ABCG2 protein, human
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters
- Multidrug Resistance-Associated Proteins
- Neoplasm Proteins
- Vidarabine
- fludarabine
- multidrug resistance-associated protein 1
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Topics |
- ATP Binding Cassette Transporter, Subfamily B, Member 1
(physiology)
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters
(biosynthesis, genetics, physiology)
- Acute Disease
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Disease-Free Survival
- Drug Resistance, Neoplasm
(drug effects, genetics)
- Female
- Gene Expression Regulation, Leukemic
- Humans
- Leukemia, Myeloid
(drug therapy, metabolism)
- Male
- Middle Aged
- Multidrug Resistance-Associated Proteins
(physiology)
- Neoplasm Proteins
(biosynthesis, genetics, physiology)
- Remission Induction
- Vidarabine
(administration & dosage, analogs & derivatives, pharmacology)
- Young Adult
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