Cholecystokinin-A receptor mediation of food intake in cats.

Abstract

The selective cholecystokinin (CCK)-B-receptor agonist and antagonist, BC 264 and L 365260, respectively, and the CCK-A-receptor antagonist, L 364718, were used to investigate the possible involvement of different classes of CCK receptors in the control of food intake induced by exogenous CCK octapeptide (CCK-8) in the cat with gastric fistula. Intravenous infusion of CCK-8 dose dependently inhibited milk intake under sham-feeding conditions, maximal inhibition reaching 52 +/- 7% (P less than 0.001) with 0.88 nmol.kg-1.h-1. L 364718 prevented this inhibition, whereas L 365260 was ineffective over the dose range tested. The reversal effect of L 364718 on 0.88 nmol.kg-1.h-1 CCK-8-induced inhibition of milk intake was observed at doses as low as 0.44 nmol.kg-1.h-1. The selective CCK-B-receptor agonist, BC 264, in doses ranging from 0.88 to 7 nmol.kg-1.h-1, had no effect on milk intake under sham-feeding conditions, although it dose dependently stimulated gastric acid output. Furthermore, neither L 364718 nor L 365260 (88 nmol.kg-1.h-1 iv) stimulated milk intake when given in the absence of CCK-8. We conclude that exogenous CCK-8 causes satiety in the cat through activation of peripheral CCK-A receptors.

• Authors: A Bado, C Durieux, L Moizo, B P Roques, M J Lewin
• Journal: The American journal of physiology (Am J Physiol) Vol. 260 Issue 4 Pt 2 Pg. R693-7 (Apr 1991) ISSN: 0002-9513 [Print] United States
• PMID: 2012242 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• BC 264
• Benzodiazepinones
• Peptide Fragments
• Phenylurea Compounds
• Receptors, Cholecystokinin
• L 365260
• Cholecystokinin
• Devazepide
• Sincalide

Topics

• Animals
• Benzodiazepinones (administration & dosage, pharmacology)
• Cats
• Cholecystokinin (administration & dosage, analogs & derivatives, pharmacology)
• Devazepide
• Dose-Response Relationship, Drug
• Eating (drug effects, physiology)
• Gastric Acid (metabolism)
• Milk
• Peptide Fragments (administration & dosage, pharmacology)
• Phenylurea Compounds
• Receptors, Cholecystokinin (antagonists & inhibitors, physiology)
• Satiation (drug effects, physiology)
• Sincalide (pharmacology)