Oseltamivir-resistant pandemic (H1N1) 2009 influenza in a severely ill patient: the first Australian case.

Abstract

After a 10-day course of oral oseltamivir for pandemic (H1N1) 2009 influenza infection, a renal transplant recipient developed rapid-onset severe primary viral pneumonia due to oseltamivir-resistant virus. Respiratory failure progressed despite high-dose oral oseltamivir, nebulised zanamivir and cessation of immunosuppressive medications, but his condition improved with intravenous zanamivir. He subsequently died of non-respiratory complications. This is the first case of oseltamivir-resistant pandemic (H1N1) 2009 in Australia and the first report of resistance in a solid organ transplant recipient.

• Authors: David J Speers, Simon H Williams, Mary Pinder, Harry R Moody, Aeron C Hurt, David W Smith
• Journal: The Medical journal of Australia (Med J Aust) Vol. 192 Issue 3 Pg. 166-8 (Feb 01 2010) ISSN: 0025-729X [Print] Australia
• PMID: 20121687 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antiviral Agents
• Oseltamivir

Topics

• Adult
• Antiviral Agents (therapeutic use)
• Australia
• Disease Outbreaks
• Drug Resistance, Viral
• Humans
• Influenza A Virus, H1N1 Subtype
• Influenza, Human (complications, drug therapy, epidemiology)
• Kidney Transplantation
• Male
• Oseltamivir (therapeutic use)