Preoperative therapy with trastuzumab and oral vinorelbine (+/- endocrine therapy) in patients with HER2-positive breast cancer.

Abstract

BACKGROUND:

Combined trastuzumab and intravenous vinorelbine yielded high clinical activity as preoperative treatment in patients (pts) with HER 2/neu positive breast cancer.

PATIENTS AND METHODS:

We tested a preoperative combination of trastuzumab with oral vinorelbine (oV) in pts with locally advanced (T2-T4 N0-3 M0) HER2-positive breast cancer. Trastuzumab was administered i.v q 3 wks and oV was administered at the dose of 55 mg/sqm on days 1 and 3 q 3 wks, for 8 courses. Pts with ER > or = 10% tumors received endocrine therapy with letrozole 2.5 mg/day, plus monthly triptorelin if premenopausal.

RESULTS:

Forty-five pts entered the study. The overall response rate (CR + PR) was 76% (95% CI: 60%-87%). pCR was observed in 4 pts (10%). Among ER-positive tumors 21/25 pts obtained a clinical response (84%) and two pts obtained a pCR (8%).

CONCLUSIONS:

The combination of trastuzumab and oral vinorelbine demonstrated encouraging activity in patients with HER 2 positive ER-positive tumors. Alternative strategies should be investigated in patients with endocrine non responsive disease.

• Authors: Monica Iorfida, Vincenzo Bagnardi, Alessandra Balduzzi, Silvia Dellapasqua, Anna Cardillo, Alberto Luini, Mattia Intra, Ida Minchella, Paolo Veronesi, Giuseppe Viale, Aron Goldhirsch, Marco Colleoni
• Journal: Breast (Edinburgh, Scotland) (Breast) Vol. 19 Issue 2 Pg. 128-32 (Apr 2010) ISSN: 1532-3080 [Electronic] Netherlands
• PMID: 20117001 (Publication Type: Journal Article)
• Copyright: Copyright 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Antineoplastic Agents
• Antineoplastic Agents, Phytogenic
• Vinblastine
• Trastuzumab
• Vinorelbine

Topics

• Antibodies, Monoclonal (administration & dosage)
• Antibodies, Monoclonal, Humanized
• Antineoplastic Agents (administration & dosage)
• Antineoplastic Agents, Phytogenic (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Breast Neoplasms (drug therapy, pathology)
• Female
• Humans
• Neoplasm Staging
• Preoperative Care
• Trastuzumab
• Vinblastine (administration & dosage, analogs & derivatives)
• Vinorelbine