Hypothesis: the "metabolic memory", the new challenge of diabetes.

Abstract

Large randomized studies have established that early intensive glycaemic control reduces the risk of diabetic complications, both micro and macrovascular. However, epidemiological and prospective data support a long-term influence of early metabolic control on clinical outcomes. This phenomenon has recently been defined as "metabolic memory". Potential mechanisms for propagating this "memory" are the non-enzymatic glycation of cellular proteins and lipids, and an excess of cellular reactive oxygen and nitrogen species, in particular originated at the level of glycated-mitochondrial proteins, perhaps acting in concert with one another to maintain stress signaling. Furthermore, the emergence of this "metabolic memory" suggests the need of a very early aggressive treatment aiming to "normalize" the metabolic control and the addition of agents which reduce cellular reactive species and glycation in addition to normalizing glucose levels in diabetic patients in order to minimize long-term diabetic complications.

• Authors: Antonio Ceriello
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 86 Suppl 1 Pg. S2-6 (Dec 2009) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 20115927 (Publication Type: Journal Article)
• Copyright: Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Blood Glucose
• Glycation End Products, Advanced
• Hypoglycemic Agents

Topics

• Blood Glucose (metabolism)
• Diabetes Complications (epidemiology, prevention & control)
• Diabetes Mellitus (drug therapy, metabolism)
• Diabetes Mellitus, Type 2 (complications, metabolism)
• Diabetic Angiopathies (epidemiology, prevention & control)
• Glycation End Products, Advanced (metabolism, therapeutic use)
• Glycosylation
• Homeostasis
• Humans
• Hypoglycemic Agents (therapeutic use)