[Administration of low-dose heparin in total nutrient admixture prevents central venous catheter-related infections in neonates].

Abstract

OBJECTIVE:

Peripherally inserted central catheter (PICC) is widely used to provide a long-term access for the administration of total parenteral nutrition and medications. Catheter-related infections (CRI) are common complications of PICC. The purpose of this retrospective study was to investigate the role of low-dose heparin added to the total nutrient admixture (CTNA) in the prevention of CRI.

METHODS:

Eighty-three neonates who underwent PICC received TNA with (heparin group, n=43) or without heparin (0.5 U/mL) (control group, n=40). The incidence of CRI was compared between the two groups.

RESULTS:

The incidences of catheter obstruction (5% vs 20%) and the catheter-tip colonization (2% vs 18%) in the heparin group were significantly lower than those in the control group (p<0.05). None of the neonates in the heparin group had clinical evidence of catheter-related bloodstream infection, but 5 cases in the control group (p<0.05).

CONCLUSIONS:

The administration of low-dose heparin in TNA may decrease the incidences of catheter obstruction and CRI.

• Authors: Jun Tang, Xi-Hong Li, Hua Wang, Ying Xiong, De-Zhi Mu
• Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi) Vol. 11 Issue 12 Pg. 983-5 (Dec 2009) ISSN: 1008-8830 [Print] China
• PMID: 20113604 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Heparin

Topics

• Catheter-Related Infections (epidemiology, prevention & control)
• Catheterization, Central Venous (adverse effects)
• Female
• Heparin (administration & dosage)
• Humans
• Incidence
• Infant, Newborn
• Male
• Parenteral Nutrition, Total
• Retrospective Studies