Melotenine A, a cytotoxic monoterpenoid indole alkaloid from Melodinus tenuicaudatus.

Abstract

Melotenine A (1), an unprecedented skeleton with a 6/5/5/6/7 pentacyclic rearranged ring system, was isolated from Melodinus tenuicaudatus. The structure was elucidated by means of spectroscopic methods and further confirmed by the single-crystal X-ray diffraction analysis. A possible biogenesis was also proposed. Melotenine A exhibited potential inhibition against five human cancer cell lines.

• Authors: Tao Feng, Yan Li, Ya-Ping Liu, Xiang-Hai Cai, Yuan-Yuan Wang, Xiao-Dong Luo
• Journal: Organic letters (Org Lett) Vol. 12 Issue 5 Pg. 968-71 (Mar 05 2010) ISSN: 1523-7052 [Electronic] United States
• PMID: 20112938 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Secologanin Tryptamine Alkaloids
• melotenine A

Topics

• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Apocynaceae (chemistry)
• Cell Line, Tumor
• Crystallography, X-Ray
• Humans
• Inhibitory Concentration 50
• Magnetic Resonance Spectroscopy
• Secologanin Tryptamine Alkaloids (chemistry, isolation & purification, pharmacology)