A novel mesoporous biomaterial for treating dentin hypersensitivity.

Abstract

An ideal material has yet to be discovered that can completely treat dentin hypersensitivity; however, calcium phosphate precipitation has exhibited potential value for the treatment of dentin hypersensitivity by the occlusion of dentinal tubules. We hypothesized that a novel mesoporous silica biomaterial (nano CaO@mesoporous silica, NCMS) containing nano-sized calcium oxide particles mixed with 30% phosphoric acid can efficiently occlude dentinal tubules and significantly reduce dentin permeability, even with the presence of pulpal pressure. This highly supersaturated Ca(2+)-and HPO(4)(2-)ion-containing NCMS paste was brushed onto dentin surfaces, and the ions diffused deeply into the dentinal tubules and formed a CaHPO(4).2H(2)O precipitation with a depth of 100 microm. The results of the dentin permeability tests showed that the novel mesoporous material exhibited a significant reduction in dentin permeability (p < 0.05), even under simulated pulpal pressure, as compared with our previously developed material, DP-bioglass, and a commercial desensitizing material, Seal & Protect.

• Authors: Y-C Chiang, H-J Chen, H-C Liu, S-H Kang, B-S Lee, F-H Lin, H-P Lin, C-P Lin
• Journal: Journal of dental research (J Dent Res) Vol. 89 Issue 3 Pg. 236-40 (Mar 2010) ISSN: 1544-0591 [Electronic] United States
• PMID: 20110512 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biocompatible Materials
• Calcium Compounds
• Drug Carriers
• Oxides
• Resin Cements
• Seal and Protect resin cement
• Silicon Dioxide
• lime

Topics

• Analysis of Variance
• Biocompatible Materials (chemistry, therapeutic use)
• Calcium Compounds (chemistry, therapeutic use)
• Dentin (drug effects, ultrastructure)
• Dentin Sensitivity (drug therapy)
• Drug Carriers (chemistry, therapeutic use)
• Humans
• Materials Testing
• Nanoparticles (therapeutic use, ultrastructure)
• Oxides (chemistry, therapeutic use)
• Resin Cements (therapeutic use)
• Rheology
• Silicon Dioxide (chemistry, therapeutic use)