[Influence of Kurarinol on specific and non-specific cell immunity in patients with chronic hepatitis B].

Abstract

OBJECTIVE:

To explore influence of Kurarinol on specific and non-specific cell immunity in patients with chronic hepatitis B.

METHODS:

74 cases of CHB were randomly divided into two groups, 36 cases in treatment group, treated with 600 mg Kurarinol glucose injection, IV, once a day. After one month, Kurarinol capsule was used orally, three times a day for 2 months, 200 mg Silybin Meglumine Tablets orally, three times a day for 3 months. 38 cases in control group, only Silybin Meglumine Tablets was used, method and dosage were the same as treatment group. Compare HBV specific CTL, non-specific CTL, sub-group of T cells, changes of Th1 and Th2, negative conversion rate of HBV DNA and HBeAg of the two groups.

RESULTS:

In treatment group, 3 months after treatment with Kurarinol, HBV specific CTL is higher than that before treatment (P < 0.01), it is also higher than that of control after treatment, P < 0.05) . Non-specific CTL is higher than that before treatment (P < 0.05), it is also higher than that of control after treatment (P < 0.01). CD4 is higher than that before treatment (P <0.05), it is also higher than that of control after treatment (P < 0.01), Thl is higher than that before treatment (P < 0.05), it is also higher than that of control after treatment (P < 0.01) . Negative conversion of HBV DNA and HBeAg is higher than that of control (P < 0.01).

CONCLUSION:

Kurarinol can improve specific and non-specific cell immunity in patients with CHB. It is one of the mechanisms that Kurarinol can clear or inhibit HBV of patients with CHB.

• Authors: Xi-Bing Gu, Xiao-Juan Yang, Dong Wang, Yin-Fang Zhu, Hong Ding, Bo Zhang, Yue-Qin Xu, Hang-Yuan Wu
• Journal: Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi) Vol. 23 Issue 4 Pg. 288-91 (Aug 2009) ISSN: 1003-9279 [Print] China
• PMID: 20108776 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Flavonoids
• Silymarin
• kurarinol
• Silybin

Topics

• Adult
• Drug Administration Schedule
• Female
• Flavonoids (administration & dosage)
• Hepatitis B, Chronic (drug therapy, immunology)
• Humans
• Immunity, Innate (drug effects)
• Male
• Middle Aged
• Silybin
• Silymarin (administration & dosage)
• T-Lymphocytes, Cytotoxic (drug effects)
• Young Adult