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Cancer chemoprevention locks onto a new polyamine metabolic target.

Abstract
Ornithine decarboxylase has a relatively long history as a target for cancer chemoprevention and chemotherapy. Plym Forshell et al. report new evidence (beginning on p. 140 in this issue of the journal) indicating that spermidine synthase, a fellow enzyme of ornithine decarboxylase in polyamine metabolism, is transactivated in part by the MYC gene and is a potential target for chemoprevention of B-cell lymphomas.
AuthorsEugene W Gerner
JournalCancer prevention research (Philadelphia, Pa.) (Cancer Prev Res (Phila)) Vol. 3 Issue 2 Pg. 125-7 (Feb 2010) ISSN: 1940-6215 [Electronic] United States
PMID20103728 (Publication Type: Comment, Journal Article, Review)
Chemical References
  • Antineoplastic Agents
  • Spermidine Synthase
Topics
  • Animals
  • Antineoplastic Agents (metabolism, pharmacology)
  • Chemoprevention (methods)
  • Humans
  • Lymphoma, B-Cell (enzymology, prevention & control)
  • Spermidine Synthase (metabolism, pharmacology)

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