Implications for cardiac surgery in patients with factor XII deficiency.

Abstract

Factor XII deficiency is associated with a prolonged activated partial thromboplastin time and activated clotting time used for monitoring during cardiopulmonary bypass. It does not predispose to an increased risk of bleeding. We present the strategy used for a case of coronary artery bypass grafting in a patient with factor XII deficiency, followed by a brief discussion of the important clinical considerations when patients with factor XII deficiency undergo cardiac surgery. Monitoring of heparin and the avoidance of anti-fibrinolytic agents are the main intraoperative issues. Postoperative care must include careful thromboembolic prophylaxis and vigilance against infection.

• Authors: Paul J Conaglen, Enoch Akowuah, Sanjay Theodore, Victoria Atkinson
• Journal: The Annals of thoracic surgery (Ann Thorac Surg) Vol. 89 Issue 2 Pg. 625-6 (Feb 2010) ISSN: 1552-6259 [Electronic] Netherlands
• PMID: 20103363 (Publication Type: Case Reports, Journal Article)
• Copyright: 2010 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

Chemical References

• Anticoagulants
• Heparin
• Factor Xa

Topics

• Aged, 80 and over
• Anticoagulants (administration & dosage)
• Cardiopulmonary Bypass (methods)
• Coronary Artery Bypass (methods)
• Coronary Disease (blood, surgery)
• Debridement
• Escherichia coli Infections (blood, surgery)
• Factor XII Deficiency (blood)
• Factor Xa (analysis)
• Heparin (administration & dosage)
• Humans
• Intraoperative Complications (blood)
• Male
• Partial Thromboplastin Time
• Plasma
• Reoperation
• Sternum (surgery)
• Surgical Flaps
• Surgical Wound Infection (blood, surgery)
• Whole Blood Coagulation Time