Abstract | BACKGROUND: HYPOTHESIS: ANIMALS: Experiment 1: Randomized placebo-controlled study, 36 sled dogs (3-8 years); Experiment 2: Randomized positive-control study, 52 sled dogs (2-8 years). METHODS: Experiment 1: Equal numbers of dogs randomly assigned to famotidine (20 mg q24h) or no treatment groups. Gastroscopy was performed 24 hours after the dogs ran 330 miles. Mucosal appearance was blindly scored by previously described scoring system. Experiment 2: Equal numbers of dogs randomly assigned to omeprazole (20 mg q24h) or high-dose famotidine (40 mg q12h) groups. Gastroscopy was performed 48 hours before and 24 hours after the dogs ran 300 miles. Mucosal appearance was blindly scored by previously described scoring system. RESULTS:
Famotidine reduced the prevalence of clinically relevant, exercise-induced gastric lesions compared with no treatment (7/16 versus 11/16, P = .031). Compared with high-dose famotidine, omeprazole significantly decreased the severity (0.4 versus 1.2, P = .0002) and prevalence (2/23 versus 7/21, P = .049) of gastric lesions. CONCLUSIONS AND CLINICAL RELEVANCE: Although famotidine provides some benefit in the prevention of exercise-induced gastric lesions, omeprazole is superior to famotidine in preventing gastritis in dogs running 300 miles. Routine administration of omeprazole is recommended to prevent stress-associated gastric disease in exercising and racing Alaskan sled dogs.
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Authors | K K Williamson, M D Willard, M E Payton, M S Davis |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
2010 Mar-Apr
Vol. 24
Issue 2
Pg. 285-8
ISSN: 0891-6640 [Print] United States |
PMID | 20102495
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Dog Diseases
(drug therapy, pathology, prevention & control)
- Dogs
- Dose-Response Relationship, Drug
- Famotidine
(administration & dosage, therapeutic use)
- Female
- Gastritis
(drug therapy, etiology, pathology, veterinary)
- Male
- Omeprazole
(therapeutic use)
- Physical Conditioning, Animal
(adverse effects)
- Stomach
(pathology)
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