Abstract | INTRODUCTION: The aim of this retrospective study was to assess ultra-rapid opiate detoxification (UROD) and to estimate the retention rate in naltrexone maintenance treatment. METHODS: RESULTS: Adverse events after UROD were prolonged unconsciousness (n=1), transient confusion (n=8) and depressive mood (n=6). The total sample showed a median OOWS score of 2 (mild withdrawal syndrome). The only two extreme outliers were found only in the subgroups "intravenous" (score 8) and "cannabis" (score 11). 96% (43/45) of the patients could be discharged the day after UROD. Thirty-six patients (80%) continued naltrexone therapy for the entire 9-month observation period. DISCUSSION: UROD and subsequently induction of naltrexone maintenance therapy can be regarded as safe and effective in patients with pure opiate addiction. Owing to cultural and economical factors our Iranian results may not correspond to European and American treatment modalities.
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Authors | A Naderi-Heiden, A Naderi, M M Naderi, F Rahmani-Didar, A-R Salimi, A Gleiss, S Kasper, R Frey |
Journal | Pharmacopsychiatry
(Pharmacopsychiatry)
Vol. 43
Issue 4
Pg. 130-7
(Jun 2010)
ISSN: 1439-0795 [Electronic] Germany |
PMID | 20101570
(Publication Type: Journal Article)
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Copyright | Copyright Georg Thieme Verlag KG Stuttgart New York. |
Chemical References |
- Narcotic Antagonists
- Naltrexone
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Topics |
- Adult
- Anesthesia, General
- Follow-Up Studies
- Humans
- Iran
(epidemiology)
- Male
- Middle Aged
- Naltrexone
(therapeutic use)
- Narcotic Antagonists
(therapeutic use)
- Opioid-Related Disorders
(drug therapy, rehabilitation)
- Retrospective Studies
- Severity of Illness Index
- Substance Withdrawal Syndrome
(prevention & control)
- Young Adult
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