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Significant stimulation of o-phthalic acid in biosynthesis of aspergiolide A by a marine fungus Aspergillus glaucus.

Abstract
The effect of o-phthalic acid (o-PA) on the production of the anti-tumor polyketide compound aspergiolide A by the marine fungus Aspergillus glaucus was investigated. o-PA at 12mM increased the aspergiolide A production by 77%. A combination of 12mM acetate with 12mM o-PA increased the production by 126%, i.e., from 27.1mg/l to 60.9mg/l, which was 27% and 75% higher than adding either 12mM o-PA or 12mM acetate, respectively. It was also found that A. glaucus could use o-PA as the sole carbon source on Minimal Medium. Ninety percent of o-PA was degraded by the fungus strain, especially when 12mM acetate was supplemented simultaneously. In culture medium supplemented with o-PA addition, sugar consumption decreased with increasing o-PA concentration, at the same time, the oxalacetate and pyruvate levels increased and the concentration of fumarate decreased. The results indicated that o-PA could stimulate biosynthesis of aspergiolide A effectively by regulating the metabolic pathway.
AuthorsXueqian Sun, Xiangshan Zhou, Menghao Cai, Jiushun Zhou, Yuanxing Zhang
JournalBioresource technology (Bioresour Technol) Vol. 101 Issue 10 Pg. 3609-16 (May 2010) ISSN: 1873-2976 [Electronic] England
PMID20100655 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2010 Elsevier Ltd. All rights reserved.
Chemical References
  • Anthraquinones
  • Culture Media
  • Phthalic Acids
  • aspergiolide A
  • phthalic acid
Topics
  • Anthraquinones (metabolism)
  • Aspergillus (drug effects, metabolism)
  • Biomass
  • Chromatography, High Pressure Liquid
  • Culture Media
  • Phthalic Acids (pharmacology)

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