Genotoxic effects of dithane M-45 on the bone marrow cells of mice in vivo.

Abstract

Genotoxic effects of dithane M-45 were studied on the bone marrow cells of male albino mice (Lacca strain) in vivo. Different doses (30 mg, 40 mg and 300 mg/kg b.wt) of dithane M-45 were injected intraperitoneally and their effects were investigated after time intervals of 1, 2, 5 and 10 days. The chromosomal aberrations observed in the bone marrow cells of male mice after treatment with dithane M-45 were fragments, rings, dicentric chromosomes, terminal chromatid deletions, chromatid gaps and breaks. In addition to these chromosomal aberrations, physiological effects such as uneven stretching of chromatin material, end-to-end chromosomal associations, exchange configurations, clumping, stickiness and centromeric associations were also observed.

• Authors: D C Gautam, L Kapoor
• Journal: Experientia (Experientia) Vol. 47 Issue 3 Pg. 280-2 (Mar 15 1991) ISSN: 0014-4754 [Print] Switzerland
• PMID: 2009939 (Publication Type: Journal Article)

Chemical References

• Chromatin
• Mutagens
• Maneb
• dithane M-45
• Zineb

Topics

• Animals
• Bone Marrow (drug effects)
• Bone Marrow Cells
• Chromatin (drug effects)
• Chromosome Aberrations
• Karyotyping
• Male
• Maneb (analogs & derivatives, toxicity)
• Mice
• Mutagenicity Tests
• Mutagens
• Zineb (analogs & derivatives, toxicity)