Efficacy and limitation of sutureless amniotic membrane transplantation for acute toxic epidermal necrolysis.

Abstract

PURPOSE:

The purpose of this case report is to describe the efficacy and limitation of ProKera, a sutureless medical device containing amniotic membrane, for treating acute ocular manifestations of toxic epidermal necrolysis (TEN).

METHODS:

ProKera was inserted in both eyes at day 10 after onset of ocular symptoms in a 5-year-old boy suffering from acute TEN, manifesting conjunctival inflammation, large conjunctival defects, pseudomembrane formation, and total corneal epithelial defects.

RESULTS:

At 9-month follow-up, insertion of ProKera resulted in complete reepithelialization, clear corneas, and vision of 20/20 in both eyes. However, because ProKera only covered the cornea and perilimbal conjunctiva, these 2 eyes still showed some conjunctival inflammation several months after discharge from the hospital. Eventually, 1 eye showed mild lid margin keratinization and cicatricial entropion, and both eyes showed trichiasis.

CONCLUSIONS:

These data suggest that ProKera, when inserted during the acute stage of TEN, may be effective in healing corneal epithelial defects and preventing corneal sequelae. Because of the limited area covered, ProKera may not prevent cicatricial complications in the fornix, tarsus, and eyelid margin as effectively as sutured amniotic membrane transplantation.

• Authors: Elizabeth Shay, John J Khadem, Scheffer C G Tseng
• Journal: Cornea (Cornea) Vol. 29 Issue 3 Pg. 359-61 (Mar 2010) ISSN: 1536-4798 [Electronic] United States
• PMID: 20098313 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural)

Topics

• Acute Disease
• Amnion (transplantation)
• Biological Dressings
• Child, Preschool
• Corneal Diseases (surgery)
• Follow-Up Studies
• Humans
• Male
• Stevens-Johnson Syndrome (surgery)
• Treatment Outcome