HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Combined mucosal and systemic immunity following pulmonary delivery of ISCOMATRIX adjuvanted recombinant antigens.

Abstract
Deep pulmonary delivery of an influenza ISCOMATRIX vaccine has previously been shown to induce a combined mucosal and systemic antibody response. To explore whether this combined response is influenced by intrinsic properties of the component antigen, we examined the efficacy of deep pulmonary delivery of ISCOMATRIX vaccines containing different recombinant antigens, specifically gB glycoprotein from cytomegalovirus and a fragment of catalase from Helicobacter pylori. Both these vaccines induced antigen-specific mucosal and systemic immunity, as well as antigen-specific proliferative cellular responses. Pulmonary immunisation with ISCOMATRIX vaccines may therefore be a generic way of inducing combined systemic and mucosal immunity.
AuthorsAna Vujanic, Janet L K Wee, Kenneth J Snibson, Stirling Edwards, Martin Pearse, Charles Quinn, Margaret Moloney, Shirley Taylor, Jean-Pierre Y Scheerlinck, Philip Sutton
JournalVaccine (Vaccine) Vol. 28 Issue 14 Pg. 2593-7 (Mar 19 2010) ISSN: 1873-2518 [Electronic] Netherlands
PMID20096391 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2010 Elsevier Ltd. All rights reserved.
Chemical References
  • Adjuvants, Immunologic
  • Antibodies, Bacterial
  • Antibodies, Viral
  • Antigens, Bacterial
  • Antigens, Viral
  • Drug Combinations
  • ISCOMATRIX
  • Phospholipids
  • Saponins
  • Vaccines, Synthetic
  • Viral Envelope Proteins
  • glycoprotein B, Simplexvirus
  • Cholesterol
  • Catalase
Topics
  • Adjuvants, Immunologic (administration & dosage)
  • Administration, Inhalation
  • Animals
  • Antibodies, Bacterial (blood)
  • Antibodies, Viral (blood)
  • Antigens, Bacterial (immunology)
  • Antigens, Viral (immunology)
  • Catalase (immunology)
  • Cell Proliferation
  • Cholesterol (administration & dosage)
  • Drug Combinations
  • Female
  • Helicobacter pylori (enzymology)
  • Injections, Subcutaneous
  • Lymphocytes (immunology)
  • Phospholipids (administration & dosage)
  • Saponins (administration & dosage)
  • Sheep
  • Vaccines, Synthetic (immunology)
  • Viral Envelope Proteins (immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: