Abstract |
Deep pulmonary delivery of an influenza ISCOMATRIX vaccine has previously been shown to induce a combined mucosal and systemic antibody response. To explore whether this combined response is influenced by intrinsic properties of the component antigen, we examined the efficacy of deep pulmonary delivery of ISCOMATRIX vaccines containing different recombinant antigens, specifically gB glycoprotein from cytomegalovirus and a fragment of catalase from Helicobacter pylori. Both these vaccines induced antigen-specific mucosal and systemic immunity, as well as antigen-specific proliferative cellular responses. Pulmonary immunisation with ISCOMATRIX vaccines may therefore be a generic way of inducing combined systemic and mucosal immunity.
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Authors | Ana Vujanic, Janet L K Wee, Kenneth J Snibson, Stirling Edwards, Martin Pearse, Charles Quinn, Margaret Moloney, Shirley Taylor, Jean-Pierre Y Scheerlinck, Philip Sutton |
Journal | Vaccine
(Vaccine)
Vol. 28
Issue 14
Pg. 2593-7
(Mar 19 2010)
ISSN: 1873-2518 [Electronic] Netherlands |
PMID | 20096391
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2010 Elsevier Ltd. All rights reserved. |
Chemical References |
- Adjuvants, Immunologic
- Antibodies, Bacterial
- Antibodies, Viral
- Antigens, Bacterial
- Antigens, Viral
- Drug Combinations
- ISCOMATRIX
- Phospholipids
- Saponins
- Vaccines, Synthetic
- Viral Envelope Proteins
- glycoprotein B, Simplexvirus
- Cholesterol
- Catalase
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Topics |
- Adjuvants, Immunologic
(administration & dosage)
- Administration, Inhalation
- Animals
- Antibodies, Bacterial
(blood)
- Antibodies, Viral
(blood)
- Antigens, Bacterial
(immunology)
- Antigens, Viral
(immunology)
- Catalase
(immunology)
- Cell Proliferation
- Cholesterol
(administration & dosage)
- Drug Combinations
- Female
- Helicobacter pylori
(enzymology)
- Injections, Subcutaneous
- Lymphocytes
(immunology)
- Phospholipids
(administration & dosage)
- Saponins
(administration & dosage)
- Sheep
- Vaccines, Synthetic
(immunology)
- Viral Envelope Proteins
(immunology)
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