The protective effect of radicicol against renal ischemia--reperfusion injury in mice.

Abstract

Overexpression of heat shock protein 70 kDa (HSP70) is known to confer cellular protection against ischemia-reperfusion (I/R) injury. Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein. Here we studied whether radicicol attenuated renal I/R injury in vivo. Treatment of mice with radicicol ameliorated renal I/R injury and increased renal HSP70 mRNA and protein. Administration of radicicol with quercetin, an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol. Our results suggest that the up-regulation of renal HSP70 protein by radicicol leads to a novel drug therapy against renal I/R injury.

• Authors: Hiroko Sonoda, Worapat Prachasilchai, Hiroaki Kondo, Naoko Yokota-Ikeda, Sayaka Oshikawa, Katsuaki Ito, Masahiro Ikeda
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 112 Issue 2 Pg. 242-6 ( 2010) ISSN: 1347-8648 [Electronic] Japan
• PMID: 20093793 (Publication Type: Journal Article)

Chemical References

• HSP70 Heat-Shock Proteins
• HSP90 Heat-Shock Proteins
• Macrolides
• RNA, Messenger
• Quercetin
• monorden

Topics

• Animals
• HSP70 Heat-Shock Proteins (drug effects, genetics, metabolism)
• HSP90 Heat-Shock Proteins (antagonists & inhibitors)
• Kidney (drug effects, pathology)
• Macrolides (pharmacology)
• Male
• Mice
• Quercetin (pharmacology)
• RNA, Messenger (drug effects, metabolism)
• Reperfusion Injury (prevention & control)
• Up-Regulation (drug effects)