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Degradation of and tissue reaction to biodegradable poly(L-lactide) for use as internal fixation of fractures: a study in rats.

Abstract
Samples of high-molecular-weight poly(L-lactide) (PLLA) (Mv = 9.0 x 10(5), a biomaterial developed for plates and screws used in internal fixation of jaw fractures, were implanted subcutaneously in the backs of rats to study tissue reaction to PLLA and to follow the degradation process. The PLLA seemed to follow the degradation pattern typical of biodegradable polyesters. After pure hydrolysis up to about 104 wk, phagocytic activity of macrophages was found at about 143 wk. Full resorption of PLLA was not demonstrated in this study. Except for the early and final parts of the implant period, no acute or chronic inflammatory reaction was observed. No implant was rejected. It is estimated that more than 3 yr will be required for total resorption of PLLA. For bone-healing this long period is of no practical importance. There is no need for removal of PLLA after fracture healing as is the case with metal fixation devices. Thus, PLLA has potential application in internal fixation of fractures and osteotomies in the maxillofacial region and other fractures that are not too heavily loaded in the human body.
AuthorsR R Bos, F R Rozema, G Boering, A J Nijenhuis, A J Pennings, A B Verwey, P Nieuwenhuis, H W Jansen
JournalBiomaterials (Biomaterials) Vol. 12 Issue 1 Pg. 32-6 (Jan 1991) ISSN: 0142-9612 [Print] Netherlands
PMID2009343 (Publication Type: Journal Article)
Chemical References
  • Biocompatible Materials
  • Polyesters
  • poly(lactide)
  • Collagen
Topics
  • Animals
  • Biocompatible Materials
  • Biodegradation, Environmental
  • Collagen (analysis)
  • Connective Tissue Cells
  • Dermatologic Surgical Procedures
  • Female
  • Fibroblasts (cytology)
  • Foreign-Body Reaction (physiopathology)
  • Fracture Fixation, Internal (instrumentation)
  • Molecular Weight
  • Polyesters
  • Prostheses and Implants
  • Rats
  • Rats, Inbred Strains
  • Skin (cytology)
  • Wound Healing (physiology)

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