Abstract | BACKGROUND:
Anticonvulsant drugs have been used in the management of pain since the 1960s. The clinical impression is that they are useful for chronic neuropathic pain, especially when the pain is lancinating or burning. Readers are referred to reviews of carbamazepine and gabapentin in T he Cochrane Library which replace the information on those drugs in this review. Other drugs remain unchanged at present in this review OBJECTIVES: SEARCH STRATEGY: Randomised trials of anticonvulsants in acute, chronic or cancer pain were identified by MEDLINE (1966-1999), EMBASE (1994-1999), SIGLE (1980 to 1999) and the Cochrane Controlled Trials Register (CENTRAL/CCTR) (The Cochrane Library Issue 3, 1999). In addition, 41 medical journals were hand searched. Additional reports were identified from the reference list of the retrieved papers, and by contacting investigators. Date of most recent search: September 1999. SELECTION CRITERIA: DATA COLLECTION AND ANALYSIS: Data were extracted by two independent review authors, and trials were quality scored. Numbers-needed-to-treat (NNTs) were calculated from dichotomous data for effectiveness, adverse effects and drug-related study withdrawal, for individual studies and for pooled data. MAIN RESULTS: AUTHORS' CONCLUSIONS:
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Authors | Philip J Wiffen, Sally Collins, Henry J McQuay, Dawn Carroll, Alejandro Jadad, R Andrew Moore |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 1
Pg. CD001133
(Jan 20 2010)
ISSN: 1469-493X [Electronic] England |
PMID | 20091515
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Amines
- Anticonvulsants
- Cyclohexanecarboxylic Acids
- gamma-Aminobutyric Acid
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Topics |
- Acute Disease
- Amines
(therapeutic use)
- Anticonvulsants
(therapeutic use)
- Chronic Disease
- Controlled Clinical Trials as Topic
- Cyclohexanecarboxylic Acids
(therapeutic use)
- Humans
- Pain
(drug therapy)
- Randomized Controlled Trials as Topic
- gamma-Aminobutyric Acid
(therapeutic use)
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