Casearin X, its degradation product and other clerodane diterpenes from leaves of Casearia sylvestris: evaluation of cytotoxicity against normal and tumor human cells.

Abstract

An EtOH extract of the leaves of Casearia sylvestris afforded new clerodane diterpene, casearin X, together with the known compounds casearins B, D, L, and O, and caseargrewiin F. Casearin X degraded to the corresponding dialdehyde when stored in CDCl(3). The diterpenes isolated were cytotoxic to human cancer cell lines, with caseargrewiin F being the most active and the new clerodane, casearin X, the second active compound with IC(50) values comparable to the positive control doxorubicin. All isolated diterpenes showed lower activities against normal human cells than against cancer cell lines, which might indicate a possible selective action on cancer cells. Casearin X dialdehyde was not cytotoxic to cancer cells indicating that the occurrence of these CO groups at C(18) and C(19) is incompatible with the cytotoxic activity.

• Authors: André Gonzaga dos Santos, Paulo Michel Pinheiro Ferreira, Gerardo Magela Vieira Júnior, Carla Cristina Perez, Aristeu Gomes Tininis, Geraldo Humberto Silva, Vanderlan da Silva Bolzani, Letícia Veras Costa-Lotufo, Cláudia do O Pessoa, Alberto José Cavalheiro
• Journal: Chemistry & biodiversity (Chem Biodivers) Vol. 7 Issue 1 Pg. 205-15 (Jan 2010) ISSN: 1612-1880 [Electronic] Switzerland
• PMID: 20087991 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 1-(acetyloxy)-3,5,6,6a,7,8,9,10-octahydro-10-hydroxy-7,8-dimethyl-7-(3-methylpenta-2,4-dien-1-yl)naphtho(1,8a-c)furan-3,5-diyl dibutanoate
• Antineoplastic Agents, Phytogenic
• Diterpenes, Clerodane

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, toxicity)
• Casearia (chemistry)
• Cell Line, Tumor
• Diterpenes, Clerodane (chemistry, isolation & purification, toxicity)
• Drug Screening Assays, Antitumor
• Humans
• Plant Leaves (chemistry)