[Adult-onset Still's disease with pulmonary and cardiac involvement and response to intravenous immunoglobulin].

Abstract

Cardiopulmonary manifestations of adult-onset Still's disease (AOSD) include pericarditis, pleural effusion, transient pulmonary infiltrates, pulmonary interstitial disease and myocarditis. Serositis are common but pneumonitis and myocarditis are not and bring elevated risk of mortality. They may manifest on disease onset or flares. Previously reported cases were treated with high-dose glucocorticoids and immunosupressants and, when refractory, intravenous immunoglobulin (IVIG). We report an AOSD patient whose flare presented with severe pleupneumonitis and myopericarditis and, following nonresponse to a methylprednisolone pulse, high dose of prednisone and cyclosporine A, recovered after a 2-day 1g/kg/day IVIG infusion.

• Authors: Nilton Salles Rosa Neto, Leandro Waldrich, Jozélio Freire de Carvalho, Rosa Maria Rodrigues Pereira
• Journal: Acta reumatologica portuguesa (Acta Reumatol Port) 2009 Oct-Dec Vol. 34 Issue 4 Pg. 628-32 ISSN: 2184-8777 [Electronic] Portugal
• Vernacular Title: Acometimento pulmonar e cardíaco em doença de Still do adulto e resposta à imunoglobulina intravenosa.
• PMID: 20087268 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Immunoglobulins, Intravenous
• Immunologic Factors

Topics

• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Immunologic Factors (therapeutic use)
• Male
• Middle Aged
• Myocarditis (drug therapy, etiology)
• Pericarditis (drug therapy, etiology)
• Pleuropneumonia (drug therapy, etiology)
• Still's Disease, Adult-Onset (complications, drug therapy)