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No significant effect of orally administered chemokine receptor 1 antagonist on intercellular adhesion molecule-3 expression in relapsing--remitting multiple sclerosis patients.

Abstract
We investigated the expression of intercellular adhesion molecules ICAM-1 and ICAM-3 on peripheral blood mononuclear cells in a subgroup of 34 patients with relapsing-remitting multiple sclerosis who were treated orally with the chemokine receptor 1 antagonist BX 471 in a 16-week, randomised, double-blind, placebo-controlled phase II study. ICAM-1 and ICAM-3 expression was measured by flow cytometry at different time points during and after therapy and compared using multivariate analysis of variance and non-parametric Mann Whitney test. ICAM-3 expression on CD14( +) peripheral blood mononuclear cells was increased in the verum group under therapy, but did not differ significantly between the verum and placebo groups. Most likely, this trend represents a small epiphenomenon only mediated by receptor cross-talk and feedback mechanisms.
AuthorsR Reuss, V Schreiber, A Klein, C Infante-Duarte, M Filippi, W Pabst, C Pohl, P Oschmann
JournalMultiple sclerosis (Houndmills, Basingstoke, England) (Mult Scler) Vol. 16 Issue 3 Pg. 366-9 (Mar 2010) ISSN: 1477-0970 [Electronic] England
PMID20086017 (Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, CD
  • CCR1 protein, human
  • Cell Adhesion Molecules
  • ICAM3 protein, human
  • Immunologic Factors
  • Lipopolysaccharide Receptors
  • Phenylurea Compounds
  • Piperidines
  • Receptors, CCR1
  • Intercellular Adhesion Molecule-1
  • BX 471
Topics
  • Administration, Oral
  • Antigens, CD (blood)
  • Cell Adhesion Molecules (blood)
  • Double-Blind Method
  • Flow Cytometry
  • Germany
  • Humans
  • Immunologic Factors (administration & dosage)
  • Intercellular Adhesion Molecule-1 (blood)
  • Italy
  • Leukocytes, Mononuclear (drug effects, immunology)
  • Lipopolysaccharide Receptors (blood)
  • Multiple Sclerosis, Relapsing-Remitting (drug therapy, immunology)
  • Phenylurea Compounds (administration & dosage)
  • Piperidines (administration & dosage)
  • Receptors, CCR1 (antagonists & inhibitors)
  • Time Factors
  • Treatment Outcome

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