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IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections.

Abstract
IL-23 plays an important role in autoimmune tissue inflammation and induces the generation of not fully characterized effector cells that mediate protection against pathogens. In this paper, we established the essential role of IL-23R in the host response against intracellular pathogens. IL-23 was critical for the expansion or maintenance of gammadelta and double negative (DN) alphabeta T cells. These cells were rapidly recruited to the site of infection and produced large amounts of IL-17, IFN-gamma, and TNF-alpha. Notably, DN T cells transferred into L. monocytogenes-infected RAG2(-/-) mice prevented bacterial growth, confirming their protective role against intracellular pathogens. Our results show that IL-23 regulates the function of IL-17-producing gammadelta and DN T cells, two essential components of the early protective immune response directed against intracellular pathogens.
AuthorsLorena Riol-Blanco, Vanja Lazarevic, Amit Awasthi, Meike Mitsdoerffer, Brian S Wilson, Andy Croxford, Ari Waisman, Vijay K Kuchroo, Laurie H Glimcher, Mohamed Oukka
JournalJournal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 184 Issue 4 Pg. 1710-20 (Feb 15 2010) ISSN: 1550-6606 [Electronic] United States
PMID20083652 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • CD4 Antigens
  • CD8 Antigens
  • Il23a protein, mouse
  • Interleukin-17
  • Interleukin-23 Subunit p19
  • Receptors, Antigen, T-Cell, alpha-beta
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Interleukin
  • Tumor Necrosis Factor-alpha
  • interleukin-23 receptor, mouse
  • Interferon-gamma
Topics
  • Animals
  • CD4 Antigens (metabolism)
  • CD8 Antigens (metabolism)
  • Cell Movement (immunology)
  • Cells, Cultured
  • Coculture Techniques
  • Immunophenotyping
  • Interferon-gamma (biosynthesis)
  • Interleukin-17 (biosynthesis, genetics)
  • Interleukin-23 Subunit p19 (physiology)
  • Listeriosis (genetics, immunology, pathology)
  • Mice
  • Mice, Knockout
  • Mice, Nude
  • Mice, Transgenic
  • Peritoneum (cytology, immunology, metabolism)
  • Receptors, Antigen, T-Cell, alpha-beta
  • Receptors, Antigen, T-Cell, gamma-delta (biosynthesis)
  • Receptors, Interleukin (deficiency, genetics, physiology)
  • T-Lymphocyte Subsets (immunology, metabolism, microbiology)
  • Tumor Necrosis Factor-alpha (biosynthesis)

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