Polybrominated diphenyl ethers (
PBDE) are a class of brominated
flame retardants that are recognized as global environmental contaminants with potential adverse effects on human health. This study examined the effects of prenatal exposure to
PBDE on reproductive organs, neuronal development, and levels of
thyroid hormones. Pregnant rats were exposed to the vehicle or deca-bromodiphenyl
ether (BDE) (BDE-209; 5, 40, or 320 mg/kg
body weight/d) during gestation days (GD) 6-18. There was a significant decrease in
body weight gain in F1 male offspring exposed to high-dose (320 mg/kg)
BDE-209. Significant increases in thyroid weight and a decrease in adrenal weight were observed in high-dose
BDE-209.
Thyroxine (T4) concentrations were significantly lower in F1 female offspring exposed to
BDE-209 at postnatal day (PND) 42. This reduction was more pronounced in the group exposed to higher doses. A low dose (5 mg/kg) of
BDE-209 significantly reduced serum
estradiol concentration in female offspring but did not affect
testosterone levels in males. There was no significant effect on hippocampal neurogenesis in
BDE-209 treatment groups. In conclusion, there was no apparent association between
thyroid hormone concentrations and low birth weight in F1 rats after gestational exposure to
BDE-209.