Tyrosine phosphatase SHP-1 in allergic and anaphylactic inflammation.

Abstract

Protein tyrosine phosphatase SHP-1 is an essential regulatory molecule in many different signaling pathways. The biological importance of SHP-1 is underscored by the motheaten mutant mouse strains with immunological disorders involving multiple organs and by the close association of aberrant SHP-1 expression with several human diseases. Recent studies provided some compelling evidence that supports a role of SHP-1 in regulating mast cell development and function and also in regulating type 2 allergic inflammatory responses in both innate and adaptive immune responses. In this article, we summarize the recent advancement of our understanding of this interesting phosphatase in the important area of allergic inflammation.

• Authors: Zhou Zhu, Sun Young Oh, You Sook Cho, Li Zhang, Yoon-Keun Kim, Tao Zheng
• Journal: Immunologic research (Immunol Res) Vol. 47 Issue 1-3 Pg. 3-13 (Jul 2010) ISSN: 1559-0755 [Electronic] United States
• PMID: 20077161 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Protein Tyrosine Phosphatase, Non-Receptor Type 6

Topics

• Anaphylaxis (immunology)
• Animals
• Cell Differentiation
• Humans
• Hypersensitivity (immunology)
• Inflammation
• Lung (immunology, metabolism)
• Mast Cells (cytology)
• Mice
• Protein Tyrosine Phosphatase, Non-Receptor Type 6 (metabolism)
• Signal Transduction