[Successful treatment of chronic disseminated intravascular coagulation syndrome with continuous subcutaneous infusion of heparin using a mobile infusion pump: report of 2 cases].

Abstract	We report here two patients with chronic disseminated intravascular coagulation (chronic DIC) secondary to aortic aneurysm, who were successfully treated with continuous subcutaneous infusion of heparin. The patients were 69- and 89-year-old males, who were admitted to our hospital because of thrombocytopenia and marked bleeding tendency. The underlying conditions were aortic dissection and aortic aneurysm, respectively. Coagulation test demonstrated that these patients had DIC, and a diagnosis of chronic DIC secondary to aortic aneurysm was made. Anti-coagulation treatment with oral camostat mesylate and daily subcutaneous infusion of heparin calcium was started. However, the treatment was insufficient to control chronic DIC, and these patients developed recurrent severe subcutaneous hemorrhages. Therefore, we attempted continuous subcutaneous infusion of heparin using a mobile infusion pump. This delivery of heparin markedly improved the coagulopathy, and the hemorrhagic episode disappeared with good compliance in the use of infusion equipment in these patients. Continuous subcutaneous infusion of heparin using a mobile infusion pump is effective and useful for long term treatment of chronic DIC by the outpatient department.
Authors	Katsuhiro Togami, Yuya Nagai, Hiroshi Arima, Sonoko Shimoji, Takahiro Kimura, Daichi Inoue, Minako Mori, Haruyuki Fujita, Sumie Tabata, Masayuki Kurata, Soshi Yanagida, Akiko Matsushita, Kenichi Nagai, Shuichiroh Kaji, Takayuki Takahashi
Journal	[Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 50 Issue 12 Pg. 1700-5 (Dec 2009) ISSN: 0485-1439 [Print] Japan
PMID	20068277 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References	Anticoagulants Heparin
Topics	Aged Aged, 80 and over Aortic Dissection (complications) Anticoagulants (administration & dosage) Aortic Aneurysm (complications) Chronic Disease Disseminated Intravascular Coagulation (drug therapy, etiology) Heparin (administration & dosage) Humans Infusion Pumps Infusions, Subcutaneous Male Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!