[Change from inflammation to carcinoma in ulcerative colitis: the role of PTEN/PI3K/AKT].

Abstract

OBJECTIVE:

To detect the changes of expression of PTEN protein and AKT protein in patients with Ulcerative Colitis (UC) in the pathway from inflammation to carcinoma.

METHODS:

A total of 110 paraffin colorectal sections were examined, which included 65 cases with UC, 25 cases with colorectal cancer and 25 cases with normal tissues. The expression of PTEN protein and AKT protein was detected with immunohistochemistry.

RESULTS:

(1) The patients with UC had lower expression of PTEN protein and higher expression of AKT than those with normal tissues (P < 0.01). (2) The patients with UC had higher expression of PTEN protein and lower expression of AKT protein than those with colorectal cancer (P < 0.01). (3) With the progress of UC, the expression of PTEN protein decreased while the expression of AKT protein increased (P < 0.01). (4) The expression of PTEN protein was negatively correlated with the expression with AKT protein in patients with UC and colorectal cancer (r = -0. 542 and -0. 674, respectively P < 0.01).

CONCLUSION:

The change of expressions of PTEN protein and AKT protein might play an important role in the development of UC and colorectal cancer. Decreased PTEN protein and increased AKT protein might be a marker for the early detection of the occurrence of colorectal cancer in patients with UC.

• Authors: Dai-Gang Fu, Xiao-Li Huang, Hua-Tian Gan, De-Kui Zhang, Li-Qiang Zhao
• Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban) Vol. 40 Issue 6 Pg. 1021-3, 1052 (Nov 2009) ISSN: 1672-173X [Print] China
• PMID: 20067111 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Phosphatidylinositol 3-Kinases
• Proto-Oncogene Proteins c-akt
• PTEN Phosphohydrolase
• PTEN protein, human

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Cell Transformation, Neoplastic (metabolism)
• Colitis, Ulcerative (metabolism, pathology)
• Female
• Humans
• Male
• Middle Aged
• PTEN Phosphohydrolase (metabolism)
• Phosphatidylinositol 3-Kinases (metabolism)
• Proto-Oncogene Proteins c-akt (metabolism)
• Young Adult