Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex.

Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), which entered several phase I and II clinical trials as an antitumor chemotherapeutic agent, was found to possess intrinsic fluorescence properties (lambda(ex) = 360 nm), which enabled us to monitor the uptake and intracellular distribution in living human cancer cells by fluorescence microscopy.
AuthorsChristian R Kowol, Robert Trondl, Vladimir B Arion, Michael A Jakupec, Irene Lichtscheidl, Bernhard K Keppler
JournalDalton transactions (Cambridge, England : 2003) (Dalton Trans) Vol. 39 Issue 3 Pg. 704-6 (Jan 21 2010) ISSN: 1477-9234 [Electronic] England
PMID20066211 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Organometallic Compounds
  • Pyridines
  • Thiosemicarbazones
  • 3-aminopyridine-2-carboxaldehyde thiosemicarbazone
  • Zinc
  • Antineoplastic Agents (chemistry, metabolism, pharmacology)
  • Cell Line, Tumor
  • Cell Survival (drug effects)
  • Fluorescence
  • Humans
  • Microscopy, Fluorescence
  • Organometallic Compounds (chemistry, metabolism, pharmacology)
  • Pyridines (chemistry)
  • Thiosemicarbazones (chemistry)
  • Zinc (chemistry)

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