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HIV protease inhibitors, indinavir or nelfinavir, augment antimalarial action of artemisinin in vitro.

Abstract
Most malaria endemic regions are co-infested with HIV infection. Treatment of one may affect outcome of the other in co-infected individuals. HIV protease inhibitors, indinavir or nelfinavir, are important antiretroviral drugs and artemisinin is central to malaria treatment. We show these protease inhibitors augment the antimalarial activity of artemisinin against P. falciparum in vitro.
AuthorsLokesh C Mishra, Amit Bhattacharya, Manish Sharma, Virendra K Bhasin
JournalThe American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 82 Issue 1 Pg. 148-50 (Jan 2010) ISSN: 1476-1645 [Electronic] United States
PMID20065012 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antimalarials
  • Artemisinins
  • HIV Protease Inhibitors
  • Indinavir
  • artemisinin
  • Nelfinavir
Topics
  • Antimalarials (administration & dosage, therapeutic use)
  • Artemisinins (administration & dosage, therapeutic use)
  • HIV Infections (complications, drug therapy)
  • HIV Protease Inhibitors (administration & dosage, therapeutic use)
  • Humans
  • Indinavir (administration & dosage, therapeutic use)
  • Malaria (complications, drug therapy)
  • Nelfinavir (administration & dosage, therapeutic use)

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