DBH deficiency in an elderly patient: efficacy and safety of chronic droxidopa.

Abstract

We describe the effects of chronic droxidopa in a patient with Dopamine beta-hydroxylase deficiency diagnosed at the age of 73. Investigations were performed to assess sympathetic activity (MIBG scintigraphy, catecholamines) and cardiovascular droxidopa safety.

• Authors: Fabien Despas, A Pathak, M Berry, R Cagnac, P Massabuau, E Liozon, M Galinier, J M Senard
• Journal: Clinical autonomic research : official journal of the Clinical Autonomic Research Society (Clin Auton Res) Vol. 20 Issue 3 Pg. 205-7 (Jun 2010) ISSN: 1619-1560 [Electronic] Germany
• PMID: 20063034 (Publication Type: Case Reports, Journal Article)

Chemical References

• Catecholamines
• Radiopharmaceuticals
• 3-Iodobenzylguanidine
• Dopamine beta-Hydroxylase
• Droxidopa

Topics

• 3-Iodobenzylguanidine
• Aged
• Autonomic Nervous System Diseases (diagnosis, diagnostic imaging, drug therapy, enzymology)
• Catecholamines (blood)
• Dopamine beta-Hydroxylase (deficiency)
• Droxidopa (therapeutic use)
• Humans
• Hypotension, Orthostatic (complications)
• Male
• Radionuclide Imaging
• Radiopharmaceuticals