Abstract |
We studied the clinical and instrumental modifications of 20 patients (mean age: 67.95 +/- 1.23 years; 13 males, 7 females) suffering from COPD (less than 65% theoretical FEV1), during treatment with bamiphylline. At basal time, and after 1, 2, 3, 4, and 6 months of therapy we performed a clinical and spirometric examination. All spirometric parameters (FEV1, VC, MEF25-75, Tiffeneau Index) increased significantly (p less than 0.01 - ANOVA1) since the first control performed after 1 month of treatment. This trend was confirmed in the successive controls. Analogue results were observed for emogasanalytical (P-CO2-PO2) and clinical ( cough and dyspnoea) parameters. During the experimental research we did not observe side effects due to the xanthine-derivative ( bamiphylline) under study or modifications of the main haematochemical tests. Therefore we believe that bamiphylline must be considered an effective therapeutic tool for COPD therapy.
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Authors | R Cogo, G P Monzani, M Fusillo, M Vota |
Journal | Minerva medica
(Minerva Med)
Vol. 82
Issue 3
Pg. 115-8
(Mar 1991)
ISSN: 0026-4806 [Print] Italy |
Vernacular Title | Valutazione dell'efficacia terapeutica della bamifillina in pazienti anziani affetti da BPCO. |
PMID | 2006029
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Bronchodilator Agents
- Theophylline
- bamifylline
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Topics |
- Aged
- Bronchodilator Agents
(therapeutic use)
- Dyspnea
(drug therapy, etiology)
- Female
- Humans
- Lung Diseases, Obstructive
(complications, drug therapy)
- Male
- Respiratory Function Tests
- Theophylline
(analogs & derivatives, therapeutic use)
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