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[Therapeutic effectiveness of bamifylline in elderly patients with COPD].

Abstract
We studied the clinical and instrumental modifications of 20 patients (mean age: 67.95 +/- 1.23 years; 13 males, 7 females) suffering from COPD (less than 65% theoretical FEV1), during treatment with bamiphylline. At basal time, and after 1, 2, 3, 4, and 6 months of therapy we performed a clinical and spirometric examination. All spirometric parameters (FEV1, VC, MEF25-75, Tiffeneau Index) increased significantly (p less than 0.01 - ANOVA1) since the first control performed after 1 month of treatment. This trend was confirmed in the successive controls. Analogue results were observed for emogasanalytical (P-CO2-PO2) and clinical (cough and dyspnoea) parameters. During the experimental research we did not observe side effects due to the xanthine-derivative (bamiphylline) under study or modifications of the main haematochemical tests. Therefore we believe that bamiphylline must be considered an effective therapeutic tool for COPD therapy.
AuthorsR Cogo, G P Monzani, M Fusillo, M Vota
JournalMinerva medica (Minerva Med) Vol. 82 Issue 3 Pg. 115-8 (Mar 1991) ISSN: 0026-4806 [Print] Italy
Vernacular TitleValutazione dell'efficacia terapeutica della bamifillina in pazienti anziani affetti da BPCO.
PMID2006029 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Bronchodilator Agents
  • Theophylline
  • bamifylline
Topics
  • Aged
  • Bronchodilator Agents (therapeutic use)
  • Dyspnea (drug therapy, etiology)
  • Female
  • Humans
  • Lung Diseases, Obstructive (complications, drug therapy)
  • Male
  • Respiratory Function Tests
  • Theophylline (analogs & derivatives, therapeutic use)

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