[Effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes].

Abstract

OBJECTIVE:

To investigate the effects of ShenSongYangXin on action potential and some current channels in isolated rabbit pulmonary vein cardiomyocytes and to elucidate its possible mechanism of curing atrial fibrillation.

METHODS:

Action potentials as well as L-type calcium channel current (I(Ca-L)), transient outward potassium current (I(K1)) and inward rectifier potassium current (I(To)) were recorded using whole cell patch-clamp technique.

RESULTS:

ShenSongYangXin prolonged the action potential duration (APD) significantly, APD90 was enlarged from (187 +/- 49) ms to (286 +/- 76) ms at the concentration of 5 mg/ml and to (312 +/- 82) ms at the concentration of 10 mg/dl respectively (P < 0.05). It also depressed the current of I(Ca-L), I(K1) and Iro in a concentration-dependent manner.

CONCLUSION:

ShenSongYangXin can be used to treat atrial fibrillation through its actions on multiple current channels.

• Authors: Liang Shi, Xin-Chun Yang, Xiu-Lan Liu, Min Zong, Yi-Ling Wu
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 89 Issue 30 Pg. 2142-6 (Aug 11 2009) ISSN: 0376-2491 [Print] China
• PMID: 20058622 (Publication Type: English Abstract, Journal Article)

Chemical References

• Calcium Channels, L-Type
• Drugs, Chinese Herbal
• Potassium Channels, Inwardly Rectifying
• shensongyangxin

Topics

• Action Potentials (drug effects)
• Animals
• Atrial Fibrillation
• Calcium Channels, L-Type (metabolism)
• Cells, Cultured
• Drugs, Chinese Herbal (pharmacology)
• Female
• Male
• Myocytes, Cardiac (drug effects, metabolism)
• Patch-Clamp Techniques
• Potassium Channels, Inwardly Rectifying (metabolism)
• Pulmonary Veins (cytology)
• Rabbits