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A CD36 synthetic peptide inhibits silica-induced lung fibrosis in the mice.

Abstract
Silicosis is a kind of pneumoconiosis caused by inhalation of silica dust, which is characterized by lung fibrosis. The biologically active form of transforming growth factor-beta1 (TGF-beta1) plays a key role in the development of lung fibrosis. CD36 is involved in the transformation of latent TGF-beta1 (L-TGF-beta1) to active TGF-beta1. The antagonistic effect of the synthetic peptide was analyzed by the administration of CD36 (93-110) synthetic peptide to the silicosis model of mice. The hydroxyproline content of the silica + CD36 (93-110) synthetic peptide group was significantly lower than that of the other experimental groups [silica and silica + CD36 (208-225) synthetic peptide groups] (p < .05). Inflammation, fibrotic degree and distribution of collagen fibers in silicotic nodules of the silica + CD36 (93-110) synthetic peptide group were less than those of the other experimental groups. The expressions of collagen I and III of the silica + CD36 (93-110) synthetic peptide group were significantly lower than those of the other experimental groups (p < .05). CD36 (93-110) synthetic peptide reduced the tissue fibrotic pathologies and collagen accumulation in the silicosis model of mice, resulting in the decreased severity of silica-induced lung fibrosis.
AuthorsXin Wang, Lina Lv, Ying Chen, Jie Chen
JournalToxicology and industrial health (Toxicol Ind Health) Vol. 26 Issue 1 Pg. 47-53 (Feb 2010) ISSN: 1477-0393 [Electronic] England
PMID20056742 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CD36 Antigens
  • CD36 protein (93-110)
  • Collagen Type I
  • Collagen Type III
  • Peptide Fragments
  • Peptides
  • Hydroxyproline
Topics
  • Animals
  • CD36 Antigens (therapeutic use)
  • Collagen Type I (metabolism)
  • Collagen Type III (metabolism)
  • Disease Models, Animal
  • Female
  • Fibrosis
  • Hydroxyproline (metabolism)
  • Inhalation Exposure
  • Lung (metabolism, pathology)
  • Mice
  • Mice, Inbred ICR
  • Peptide Fragments (therapeutic use)
  • Peptides (therapeutic use)
  • Silicosis (drug therapy, metabolism)

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