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Antibody persistence six years after two doses of combined hepatitis A and B vaccine.

Abstract
Persistent immunity to hepatitis A and hepatitis B antibodies six years after vaccination of adolescents (aged 12-15 years) with a combined hepatitis A and B (HAB) vaccine following a 0, 6 month or a 0, 12 month schedule was assessed. Yearly (Year-2-6) serum samples were tested for anti-HAV and anti-HBs using EIA. Subjects with anti-HBs concentrations <10 mIU/mL (14/23) at Year-5 or Year-6, received an additional HBV vaccine dose approximately 12 months after Year-6. Blood samples were collected pre-booster and 1 month post-booster to assess booster response. 240 subjects were vaccinated in the study; at Year-6, data were available from 88 subjects. At that time 84.8% (39/46; 0, 6 month) and 92.9% (39/42; 0, 12 month) of subjects had anti-HBs concentrations > or = 10 mIU/mL. All but one of the 14 boosted subjects responded to the additional HBV vaccine dose with anti-HBs concentrations > or = 100 mIU/mL. All seroconverted subjects who returned at Year-6 were seropositive for anti-HAV. Simplification, reduced number of doses and similar long-term persistence of immunity make the 0, 6 month and 0, 12 month schedule preferable for immunization against HAV/HBV in this population.
AuthorsMargaret A Burgess, Peter B McIntyre, Margaret Hellard, Tilman A Ruff, Inge Lefevre, Hans L Bock
JournalVaccine (Vaccine) Vol. 28 Issue 10 Pg. 2222-2226 (Mar 02 2010) ISSN: 1873-2518 [Electronic] Netherlands
PMID20056187 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2010 Elsevier Ltd. All rights reserved.
Chemical References
  • Hepatitis A Antibodies
  • Hepatitis A Vaccines
  • Hepatitis B Antibodies
  • Hepatitis B Vaccines
  • Vaccines, Combined
Topics
  • Adolescent
  • Child
  • Female
  • Hepatitis A Antibodies (blood)
  • Hepatitis A Vaccines (immunology)
  • Hepatitis B Antibodies (blood)
  • Hepatitis B Vaccines (immunology)
  • Humans
  • Immunization, Secondary (methods)
  • Male
  • Time Factors
  • Vaccination (methods)
  • Vaccines, Combined (immunology)
  • Young Adult

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