Abstract | BACKGROUND: METHODS: In a randomised, double-blind, placebo-controlled trial in 16 patients undergoing bilateral knee arthroplasty with high-volume local infiltration analgesia in the deeper layers, saline or ropivacaine 2 mg/ml was infiltrated into the subcutaneous part of the wound in each knee along with the placement of multi-fenestrated catheters in the subcutaneous wound layers in both knees. Pain was assessed for 6 h post-operatively and for 3 h after a bolus injection given through the catheter 24 h post-operatively. RESULTS: Visual analogue scale (VAS) pain scores were significantly lower from the knee infiltrated with ropivacaine compared with the knee infiltrated with saline in the subcutaneous layer of the wound, at rest (P<0.02), with flexion of the knee (P<0.04) and when the leg was straight and elevated (P<0.04). Twenty-four hours post-operatively, a decline in the VAS pain scores was observed in both groups, with no statistically significant difference between injection of ropivacaine or saline in the subcutaneously placed catheters (P>0.05). CONCLUSION:
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Authors | L Ø Andersen, H Husted, B B Kristensen, K S Otte, L Gaarn-Larsen, H Kehlet |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 54
Issue 5
Pg. 543-8
(May 2010)
ISSN: 1399-6576 [Electronic] England |
PMID | 20055763
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amides
- Anesthetics, Local
- Sodium Chloride
- Ropivacaine
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Amides
(administration & dosage)
- Anesthetics, Local
(administration & dosage)
- Arthroplasty, Replacement, Knee
(methods)
- Double-Blind Method
- Female
- Humans
- Injections, Subcutaneous
- Male
- Middle Aged
- Pain Measurement
- Pain, Postoperative
(prevention & control)
- Ropivacaine
- Sodium Chloride
(administration & dosage)
- Time Factors
- Wounds and Injuries
(metabolism)
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