Abstract | UNLABELLED: Methods: Leptin levels were measured in 103 consecutive women with anorexia nervosa. Results: Spine BMD and Z-score values were found to be significantly lower in the low tertile compared with the highest tertile. Duration of amenorrhea and leptin level accounted for 27% of the variance in lumbar spine BMD. INTRODUCTION: METHODS:
Leptin levels were measured consecutively in 103 women with anorexia nervosa (AN) with a mean age of 24.9 +/- 7.4 years. Osteodensitometry was also performed by dual energy X-ray absorptiometry (DXA). RESULTS: Spine bone mineral density (BMD) and Z-score values were found to be significantly lower in the low tertile compared with the highest tertile. Duration of amenorrhea and leptin level accounted for 27% of the variance in lumbar spine BMD. The mean leptin level was 3.9 +/- 4.6 ng/mL (normal values, 3.5-11 ng/mL). The distribution of leptin values was not a Gaussian distribution, and a log-transformed was therefore performed. A significant correlation was found between leptin level and spinal BMD (r = 0.3; p = 0.002); significant correlations were observed for both femoral neck and total hip BMDs. When leptin level values were divided into tertiles, spine BMD and Z-score values were found to be significantly lower in the lower tertile (p = 0.04 and p = 0.02) compared with the highest tertile. For femoral neck BMDs, the T-score was slightly lower between low and high tertile, but the difference was not statistically significant (p = 0.07). When multivariate analyses were performed, two independent factors which could possibly account for the variance in spinal BMDs were found. Duration of amenorrhea and leptin level accounted for 27% of the variance (p < 0.0001). CONCLUSION: The mechanisms underlying bone loss in AN patients remain unclear and complex, involving hypoestrogenia as well as nutritional factors such as insulin-like growth factor and leptin.
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Authors | I Legroux-Gérot, J Vignau, E Biver, P Pigny, F Collier, X Marchandise, B Duquesnoy, B Cortet |
Journal | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
(Osteoporos Int)
Vol. 21
Issue 10
Pg. 1715-22
(Oct 2010)
ISSN: 1433-2965 [Electronic] England |
PMID | 20052458
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Absorptiometry, Photon
(methods)
- Adolescent
- Adult
- Amenorrhea
(blood, etiology)
- Anorexia Nervosa
(blood, complications)
- Bone Density
(physiology)
- Female
- Femur Neck
(physiopathology)
- Hip Joint
(physiopathology)
- Humans
- Leptin
(blood)
- Lumbar Vertebrae
(physiopathology)
- Osteoporosis
(blood, etiology)
- Young Adult
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