Functional improvement with hylan G-F 20 in patients with knee osteoarthritis.

Abstract

A systematic review of randomized, controlled, prospective clinical studies is described (8 trials; N = 1674 patients), with > 100 patients in each, which evaluated functional outcomes with hylan G-F 20 in secondary analyses. Hylan G-F 20 significantly improved Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function versus appropriate/conventional care or corticosteroid, it significantly improved loss of activity versus saline, and it had similar functional improvements compared with progressive knee exercises or nonsteroidal anti-inflammatory drugs. Functional improvements with hylan G-F 20 also improved with pain relief. Hylan G-F 20 should be considered as part of a multimodal arthritis treatment regimen that focuses on improving function.

• Authors: Victoria A Brander, Teresa S Stadler
• Journal: The Physician and sportsmedicine (Phys Sportsmed) Vol. 37 Issue 3 Pg. 38-48 (Oct 2009) ISSN: 0091-3847 [Print] England
• PMID: 20048527 (Publication Type: Journal Article, Review, Systematic Review)

Chemical References

• Adrenal Cortex Hormones
• Anti-Inflammatory Agents, Non-Steroidal
• Biocompatible Materials
• hylan
• Hyaluronic Acid

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Biocompatible Materials (administration & dosage, therapeutic use)
• Combined Modality Therapy
• Disability Evaluation
• Exercise Therapy
• Humans
• Hyaluronic Acid (administration & dosage, analogs & derivatives, therapeutic use)
• Injections, Intra-Articular
• Osteoarthritis, Knee (drug therapy, physiopathology, therapy)
• Pain (drug therapy, physiopathology)
• Pain Measurement
• Paracentesis
• Randomized Controlled Trials as Topic
• Treatment Outcome