Effect of NIP-142 on potassium channel alpha-subunits Kv1.5, Kv4.2 and Kv4.3, and mouse atrial repolarization.

Abstract

Effects of NIP-142, a benzopyran compound which terminates experimental atrial arrhythmia, on potassium channel alpha-subunits and mouse atrial repolarization were examined. NIP-142 concentration-dependently blocked the outward current through potassium channel alpha subunits Kv1.5, Kv4.2 and Kv4.3 expressed in Xenopus oocytes. In isolated mouse atrial myocardia, NIP-142 prolonged the action potential duration and effective refractory period, and increased the contractile force. These results suggest that NIP-142 blocks the potassium channels underlying the transient and sustained outward currents, which may contribute to its antiarrhythmic activity.

• Authors: Hikaru Tanaka, Iyuki Namekata, Shogo Hamaguchi, Taro Kawamura, Hiroyuki Masuda, Yoshio Tanaka, Naoko Iida-Tanaka, Akira Takahara
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 33 Issue 1 Pg. 138-41 ( 2010) ISSN: 1347-5215 [Electronic] Japan
• PMID: 20045952 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Arrhythmia Agents
• Benzopyrans
• NIP142
• Shaker Superfamily of Potassium Channels

Topics

• Action Potentials (drug effects)
• Animals
• Anti-Arrhythmia Agents (pharmacology, therapeutic use)
• Atrial Fibrillation (drug therapy)
• Benzopyrans (pharmacology, therapeutic use)
• Dose-Response Relationship, Drug
• Heart Atria (drug effects)
• Mice
• Muscle Contraction (drug effects)
• Myocardium (chemistry)
• Oocytes
• Shaker Superfamily of Potassium Channels (antagonists & inhibitors)
• Xenopus