Abstract | BACKGROUND: AIMS: METHOD: A Cochrane Collaboration systematic review and meta-analysis of randomised comparisons of drug v. placebo, drug v. drug, or single drug v. combined drug treatment in adult patients with borderline personality disorder was conducted. Primary outcomes were overall disorder severity as well as specific core symptoms. Secondary outcomes comprised associated psychiatric pathology and drug tolerability. RESULTS: CONCLUSIONS: The current evidence from randomised controlled trials suggests that drug treatment, especially with mood stabilisers and second-generation antipsychotics, may be effective for treating a number of core symptoms and associated psychopathology, but the evidence does not currently support effectiveness for overall severity of borderline personality disorder. Pharmacotherapy should therefore be targeted at specific symptoms.
|
Authors | Klaus Lieb, Birgit Völlm, Gerta Rücker, Antje Timmer, Jutta M Stoffers |
Journal | The British journal of psychiatry : the journal of mental science
(Br J Psychiatry)
Vol. 196
Issue 1
Pg. 4-12
(Jan 2010)
ISSN: 1472-1465 [Electronic] England |
PMID | 20044651
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
|
Chemical References |
- Antidepressive Agents
- Antipsychotic Agents
- Fatty Acids, Omega-3
- Serotonin Uptake Inhibitors
|
Topics |
- Antidepressive Agents
(therapeutic use)
- Antipsychotic Agents
(therapeutic use)
- Borderline Personality Disorder
(drug therapy)
- Drug Therapy, Combination
- Fatty Acids, Omega-3
(therapeutic use)
- Female
- Humans
- Male
- Randomized Controlled Trials as Topic
(standards)
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- Treatment Outcome
|