Carcinogenicity study of fecapentaene-12 diacetate on skin painting in SENCAR mice.

Abstract

To investigate the effects of both diol esterification and coadministration with antioxidant on the tumorigenicity of fecapentaene-12 (FP-12) preparations, diacetylfecapentaene-12 (DAFP-12) in dimethylsulfoxide (DMSO) was applied to SENCAR mouse skin with or without the stabilizer, vitamin E, twice/week for 5 weeks, following which all animals were promoted for up to 25 weeks by weekly applications of 12-O-tetradecanoylphorbol-13-acetate (TPA). While positive controls receiving 7,12-dimethylbenz[a]anthracene (DMBA) instead of DAFP-12 in a similar protocol all developed papillomas (average of 23/animal), papilloma incidence in mice given DAFP-12 did not differ significantly from that of the vehicle control. We conclude that DAFP-12 shows little or no tumor initiating activity for mouse skin even when coadministered with vitamin E.

• Authors: D E Devor, J R Henneman, L K Keefer, D L Logsdon, J M Rice, A J Streeter, J M Ward
• Journal: Cancer letters (Cancer Lett) Vol. 56 Issue 1 Pg. 11-5 (Jan 1991) ISSN: 0304-3835 [Print] Ireland
• PMID: 2004349 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Drug Combinations
• Mutagens
• Polyenes
• diacetylfecapentaene-12
• Vitamin E
• 1-(1-glycero)dodeca-1,3,5,7,9-pentaene
• Tetradecanoylphorbol Acetate

Topics

• Adult
• Animals
• Drug Combinations
• Female
• Humans
• Mice
• Mutagens (pharmacology)
• Papilloma (chemically induced)
• Polyenes (adverse effects, pharmacology)
• Skin Neoplasms (chemically induced)
• Tetradecanoylphorbol Acetate (pharmacology)
• Vitamin E (pharmacology)