HemoHIM improves ovarian morphology and decreases expression of nerve growth factor in rats with steroid-induced polycystic ovaries.

Abstract

Estradiol valerate (EV)-induced polycystic ovaries (PCOs) in rats cause the anovulation and cystic ovarian morphology. We investigated whether treatment with HemoHIM influences the ovarian morphology and the expression of nerve growth factor (NGF) in an EV-induced PCO rat model. PCO was induced by a single intramuscular injection of EV (4 mg, dissolved in sesame oil) in adult cycling rats. HemoHIM was either administered orally (100 mg/kg of body weight/day) for 35 consecutive days or injected intraperitoneally (50 mg/kg of body weight) every other day after EV injection. Ovarian morphology was almost normalized, and NGF was normalized in the PCO + HemoHIM group. HemoHIM lowered the high numbers of antral follicles and increased the number of corpora lutea in PCOs. The results are consistent with a beneficial effect of HemoHIM in the prevention and treatment of PCO syndrome.

• Authors: Sung Ho Kim, Hae June Lee, Joong Sun Kim, Changjong Moon, Jong Choon Kim, Chun Sik Bae, Hae Ran Park, Uhee Jung, Sung Kee Jo
• Journal: Journal of medicinal food (J Med Food) Vol. 12 Issue 6 Pg. 1348-52 (Dec 2009) ISSN: 1557-7600 [Electronic] United States
• PMID: 20041792 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Plant Preparations
• Estradiol
• Nerve Growth Factor

Topics

• Animals
• Disease Models, Animal
• Estradiol (adverse effects, analogs & derivatives)
• Female
• Gene Expression (drug effects)
• Humans
• Nerve Growth Factor (genetics, metabolism)
• Ovary (drug effects, metabolism, pathology)
• Plant Preparations (administration & dosage)
• Polycystic Ovary Syndrome (chemically induced, drug therapy, metabolism, pathology)
• Random Allocation
• Rats
• Rats, Sprague-Dawley