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Discovery of indolone acetamides as novel SV2A ligands with improved potency toward seizure suppression.

AuthorsAnne Frycia, Jean-Philippe Starck, Sophie Jadot, Bénédicte Lallemand, Karine Leclercq, Patrick Lo Brutto, Alain Matagne, Valérie Verbois, Joël Mercier, Benoit Kenda
JournalChemMedChem (ChemMedChem) Vol. 5 Issue 2 Pg. 200-5 (Feb 01 2010) ISSN: 1860-7187 [Electronic] Germany
PMID20039359 (Publication Type: Journal Article)
Chemical References
  • Acetamides
  • Anticonvulsants
  • Indoles
  • Ligands
  • Membrane Glycoproteins
  • Nerve Tissue Proteins
  • Pyrrolidinones
  • Seletracetam
  • Sv2a protein, mouse
  • Levetiracetam
  • brivaracetam
  • Piracetam
Topics
  • Acetamides (chemistry, pharmacokinetics)
  • Animals
  • Anticonvulsants (chemistry, pharmacokinetics)
  • Disease Models, Animal
  • Indoles (chemistry)
  • Levetiracetam
  • Ligands
  • Membrane Glycoproteins (antagonists & inhibitors, metabolism)
  • Mice
  • Nerve Tissue Proteins (antagonists & inhibitors, metabolism)
  • Piracetam (analogs & derivatives, chemistry, pharmacology)
  • Pyrrolidinones (chemistry, pharmacology)
  • Rats
  • Seizures (drug therapy)
  • Synaptic Vesicles (metabolism)

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