Abstract | BACKGROUND AND DESIGN: RESULTS AND CONCLUSION:
Taurolidine induces cancer cell death through a variety of mechanisms. Even now, all the antineoplastic pathways it employs are not completely elucidated. It has been shown to enhance apoptosis, inhibit angiogenesis, reduce tumor adherence, downregulate proinflammatory cytokine release, and stimulate anticancer immune regulation following surgical trauma. Apoptosis is activated through both a mitochondrial cytochrome-c-dependent mechanism and an extrinsic direct pathway. A lot of in vitro and animal data support taurolidine's tumoricidal action. Taurolidine has been used as an antimicrobial agent in the clinical setting since the 1970s and thus far appears nontoxic. The nontoxic nature of taurolidine makes it a favorable option compared with current chemotherapeutic regimens. Few published clinical studies exist evaluating the role of taurolidine as a chemotherapeutic agent. The literature lacks a gold-standard level 1 randomized clinical trial to evaluate taurolidine's potential antineoplastic benefits. However, these trials are currently underway. Such randomized control studies are vital to clarify the role of taurolidine in modern cancer treatment.
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Authors | Peter M Neary, Patrick Hallihan, Jiang H Wang, Rolf W Pfirrmann, David J Bouchier-Hayes, Henry P Redmond |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 17
Issue 4
Pg. 1135-43
(Apr 2010)
ISSN: 1534-4681 [Electronic] United States |
PMID | 20039217
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents
- Thiadiazines
- Taurine
- taurolidine
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Topics |
- Animals
- Antineoplastic Agents
(therapeutic use)
- Humans
- Neoplasms
(drug therapy)
- Taurine
(analogs & derivatives, therapeutic use)
- Thiadiazines
(therapeutic use)
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