Abstract |
Injection pain has been associated with veterinary use of the antiemetic maropitant (Cerenia, Pfizer Animal Health). Cerenia is formulated using sulphobutylether- beta-cyclodextrin to bind maropitant and mitigate injection pain. The objective of this study was to determine whether the temperature of Cerenia alters binding between maropitant and sulphobutylether- beta-cyclodextrin and affects injection pain. Binding decreased as temperature increased, and Cerenia-elicited injection pain increased at warmer drug temperatures. These data suggest that the amount of free unbound maropitant increases with temperature and that injection pain increases with temperature in a similar fashion. Clinically, these studies suggest that injection of refrigerated Cerenia may significantly reduce or eliminate pain associated with SC injection of Cerenia.
|
Authors | Sunil Thomas Narishetty, Betsy Galvan, Eileen Coscarelli, Michelle Aleo, Tim Fleck, William Humphrey, Robert B McCall |
Journal | Veterinary therapeutics : research in applied veterinary medicine
(Vet Ther)
Vol. 10
Issue 3
Pg. 93-102
( 2009)
ISSN: 1528-3593 [Print] United States |
PMID | 20037963
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antiemetics
- Excipients
- Quinuclidines
- beta-Cyclodextrins
- SBE4-beta-cyclodextrin
- maropitant
|
Topics |
- Animals
- Antiemetics
(administration & dosage, adverse effects)
- Dog Diseases
(chemically induced)
- Dogs
- Excipients
- Pain
(chemically induced)
- Quinuclidines
(administration & dosage, adverse effects, chemistry)
- Refrigeration
- beta-Cyclodextrins
(chemistry)
|