Abstract | BACKGROUND: MATERIAL/METHODS:
hs-CRP concentrations and PON-1 activity with respect to carotid intima-media thickness were evaluated in 38 subclinical hypothyroidism patients (normolipidemic, mean age: 49.79+/-10.04 years) before and after 3 months of stable euthyroidism and compared with those of 19 euthyroid normolipidemic healthy individuals (mean age: 49.95+/-8.12 years). RESULTS: At baseline, the patients with subclinical hypothyroidism had similar levels of PON-1 activity and hs-CRP and a similar lipid profile as the controls; however, the carotid intima-media thickness was greater than in the controls. Levothyroxine treatment had no effect on serum PON-1 activity and hs-CRP level, but it resulted in a significant reduction in carotid intima-media thickness in the subclinical hypothyroidism patients. CONCLUSIONS: PON-1 activity and hs-CRP levels did not significantly differ between subclinical hypothyroid patients and controls. Although levothyroxine treatment might have the potential to reverse the progression of atherosclerosis in subclinical hypothyroid patients, PON-1 activity and hs-CRP levels were not affected by this treatment. The reduction in carotid intima-media thickness was independent of the decrease in serum lipid profile or other variables.
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Authors | Levent Kebapcilar, Abdurrahman Comlekci, Pinar Tuncel, Ahmet Solak, Mustafa Secil, Omur Gencel, Mustafa Sahin, Ismail Sari, Sena Yesil |
Journal | Medical science monitor : international medical journal of experimental and clinical research
(Med Sci Monit)
Vol. 16
Issue 1
Pg. CR41-7
(Jan 2010)
ISSN: 1643-3750 [Electronic] United States |
PMID | 20037493
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- C-Reactive Protein
- Aryldialkylphosphatase
- Thyroxine
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Topics |
- Adult
- Aryldialkylphosphatase
(blood)
- Blood Chemical Analysis
- Body Mass Index
- Body Weights and Measures
- C-Reactive Protein
(metabolism)
- Carotid Arteries
(diagnostic imaging)
- Hormone Replacement Therapy
(methods)
- Humans
- Hypothyroidism
(blood, drug therapy, enzymology, pathology)
- Middle Aged
- Statistics, Nonparametric
- Thyroxine
- Tunica Intima
(pathology)
- Ultrasonography
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