HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Successful unrelated bone marrow transplantation for a human immunodeficiency virus type-1-seropositive acute myelogenous leukemia patient following HAART.

Abstract
The availability of highly active anti-retroviral therapy (HAART) has greatly improved the outcome of human immunodeficiency virus type-1 (HIV-1) infection and disease. We report here on a case of an HIV-1-seropositive patient with acute myelogenous leukemia who underwent a successful allogeneic unrelated bone marrow transplantation following HAART. A 40-year-old Japanese HIV-seropositive man underwent allogeneic unrelated bone marrow transplantation using a myeloablative pretransplant-conditioning regimen. Neutrophil engraftment occurred on day +18, and donor chimerism was achieved on day +27. During pre- and post- transplantation, the HAART was not interrupted. Over 1 year after transplantation, the patient is alive and in continuous complete remission with undetectable levels of HIV-1 RNA. HAART can lead to a successful hematopoietic stem cell transplantation without severe opportunistic infections.
AuthorsYoko Oka, Haruko Tashiro, Mitsuho Mizutani-Noguchi, Ichiro Koga, Toshihiko Sugao, Ryosuke Shirasaki, Toshiyuki Miura, Nobu Akiyama, Kazuo Kawasugi, Shin Fujimori, Naoki Shirafuji
JournalInternational journal of hematology (Int J Hematol) Vol. 91 Issue 1 Pg. 140-5 (Jan 2010) ISSN: 1865-3774 [Electronic] United States
PMID20033800 (Publication Type: Case Reports, Journal Article)
Chemical References
  • RNA, Viral
Topics
  • Adult
  • Antiretroviral Therapy, Highly Active
  • Bone Marrow Transplantation
  • HIV Infections (complications, drug therapy)
  • HIV-1 (drug effects, genetics)
  • Humans
  • Leukemia, Myeloid, Acute (complications, therapy)
  • Male
  • RNA, Viral
  • Remission Induction

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: