Successful unrelated bone marrow transplantation for a human immunodeficiency virus type-1-seropositive acute myelogenous leukemia patient following HAART.

The availability of highly active anti-retroviral therapy (HAART) has greatly improved the outcome of human immunodeficiency virus type-1 (HIV-1) infection and disease. We report here on a case of an HIV-1-seropositive patient with acute myelogenous leukemia who underwent a successful allogeneic unrelated bone marrow transplantation following HAART. A 40-year-old Japanese HIV-seropositive man underwent allogeneic unrelated bone marrow transplantation using a myeloablative pretransplant-conditioning regimen. Neutrophil engraftment occurred on day +18, and donor chimerism was achieved on day +27. During pre- and post- transplantation, the HAART was not interrupted. Over 1 year after transplantation, the patient is alive and in continuous complete remission with undetectable levels of HIV-1 RNA. HAART can lead to a successful hematopoietic stem cell transplantation without severe opportunistic infections.
AuthorsYoko Oka, Haruko Tashiro, Mitsuho Mizutani-Noguchi, Ichiro Koga, Toshihiko Sugao, Ryosuke Shirasaki, Toshiyuki Miura, Nobu Akiyama, Kazuo Kawasugi, Shin Fujimori, Naoki Shirafuji
JournalInternational journal of hematology (Int J Hematol) Vol. 91 Issue 1 Pg. 140-5 (Jan 2010) ISSN: 1865-3774 [Electronic] United States
PMID20033800 (Publication Type: Case Reports, Journal Article)
Chemical References
  • RNA, Viral
  • Adult
  • Antiretroviral Therapy, Highly Active
  • Bone Marrow Transplantation
  • HIV Infections (complications, drug therapy)
  • HIV-1 (drug effects, genetics)
  • Humans
  • Leukemia, Myeloid, Acute (complications, therapy)
  • Male
  • RNA, Viral
  • Remission Induction

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