[Immobilized forms of sodium hypochlorite in carboxymetilcellulose gel used in treatment of disseminated peritonitis].

56 patients with disseminated purulent peritonitis were observed. All patients were divided into 2 groups. 30 patients treated according to traditional technique formed the first group. Surgical treatment included: laparotomy, elimination of the underlying condition that caused peritonitis, nasointestinal intubation of small intestine, abdominal cavity sanation with 0.02% furacillin solution till pure liquid, drainage. 200 ml of 0.03% aqueous solution of sodium hypochlorite was infused into abdominal cavity before closure. 26 patients treated according to the similar technique formed the second group. In contrast to the first group, 200 ml of immobilized form of sodium hypochlorite in carboxymetilcellulose gel was infused to the patients from the second group before wound closure. In early postoperative period the indices of endotoxicosis were in 1.6 times lower in patients from the second group and motor-evacuatory function of the stomach--twice higher compared with the patients from the first group. It decreased the amount of complications in 2 times, and postoperative lethality--in 2.6 times. In long-term postoperative period perfect treatment results increased in 20.8%, well--in 4.1%, tolerable--decreased in 20.9% compared with the results in the control group.
AuthorsB S Sukovatykh, Iu Iu Blinkov, S A Eshotkin, O G Frolova
JournalKhirurgiia (Khirurgiia (Mosk)) Issue 11 Pg. 14-7 ( 2009) ISSN: 0023-1207 [Print] Russia (Federation)
PMID20032938 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Disinfectants
  • Drug Combinations
  • Gels
  • Carboxymethylcellulose Sodium
  • Sodium Hypochlorite
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Carboxymethylcellulose Sodium (pharmacology)
  • Disinfectants (administration & dosage, therapeutic use)
  • Drainage (methods)
  • Drug Combinations
  • Female
  • Follow-Up Studies
  • Gels
  • Humans
  • Infusions, Parenteral
  • Laparotomy (methods)
  • Male
  • Middle Aged
  • Peritonitis (therapy)
  • Sodium Hypochlorite (administration & dosage, therapeutic use)
  • Treatment Outcome
  • Young Adult

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