Wilms' tumor 1 (WT1) peptide immunotherapy for gynecological malignancy.

Abstract

BACKGROUND:

The object of this study was to investigate the safety and clinical response of immunotherapy targeting the WT1 (Wilms' tumor 1) gene product in patients with gynecological cancer.

PATIENTS AND METHODS:

Twelve patients with WT1/human leukocyte antigen (HLA)-A*2402-positive gynecological cancer were included in a Phase II clinical trial of WT1 vaccine therapy. In all the patients, the tumors were resistant to standard therapy. The patients received intradermal injections of a HLA-A*2402-restricted, modified 9-mer WT1 peptide every week for 12 weeks. Tumor size, which was measured by computed tomography (CT), was determined every 4 weeks. The responses were analyzed according to Response Evaluation Criteria in Solid Tumors (RECIST).

RESULTS:

The protocol was well tolerated; only local erythema occurred at the WT1 vaccine injection site. The clinical responses were as follows: stable disease (SD) in 3 patients and progressive disease (PD) in 9 patients. No patients had a complete (CR) or partial response (PR). The disease control rate was 25.0%.

CONCLUSION:

Although a small, uncontrolled, nonrandomized trial, this study showed that WT1 vaccine therapy for patients with gynecological cancer was safe and produced a clinical response.

• Authors: Satoshi Ohno, Satoru Kyo, Subaru Myojo, Satoshi Dohi, Junko Ishizaki, Ken-Ichi Miyamoto, Satoshi Morita, Jun-Ichi Sakamoto, Takayuki Enomoto, Tadashi Kimura, Yoshihiro Oka, Akihiro Tsuboi, Haruo Sugiyama, Masaki Inoue
• Journal: Anticancer research (Anticancer Res) Vol. 29 Issue 11 Pg. 4779-84 (Nov 2009) ISSN: 1791-7530 [Electronic] Greece
• PMID: 20032435 (Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cancer Vaccines
• HLA-A Antigens
• HLA-A*24:02 antigen
• HLA-A24 Antigen
• Peptide Fragments
• WT1 Proteins

Topics

• Adult
• Aged
• Cancer Vaccines (therapeutic use)
• Female
• Genital Neoplasms, Female (immunology, therapy)
• HLA-A Antigens (biosynthesis, immunology)
• HLA-A24 Antigen
• Humans
• Injections, Intradermal
• Middle Aged
• Peptide Fragments (administration & dosage, immunology)
• WT1 Proteins (immunology)